How Does Modafinil affect the brain?

Modafinil is a non-d-amphetaminergic psychoactive medication usually designated for the treatment of sleep, such as narcolepsy, obstructive sleep apnea symptoms, and shift work sleep disorder. Also, it is well represented in the literature that this drug improves function in several cognitive domains as well as a work memory and episodic memory. These results of Modafinil on memory have also been reported in psychiatric patients, suggesting that this drug is an excellent candidate agent for the treatment of cognitive dysfunction in psychiatric diseases. In addition, clinical research has revealed that Modafinil improves signs in patients with significant depression, bipolar disorder, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD).

The tool of action of Modafinil Australia is not understood yet; but, it is known that this medicine has an extraordinary effect on catecholamines, serotonin, glutamate, gamma amino-butyric acid, orexin, and histamine systems in the brain. Also, studies show that this smart drug restrains the dopamine transporter, growing the dopaminergic neurotransmission in the vigilance circuits. Psychostimulants such as amphetamine, which also work on several neurotransmitter systems, have been shown to have a noticeable impact on behavior, involving the production of doubt, fear, and hyperactivity. Still, this nootropic is less relevant to side effects such as hyperactivity, nervousness, jitteriness, or rebound consequences than the common drugs.

Any studies recommended that psychostimulant management can begin oxidative stress in the rat brain. The brain is especially exposed to reactive oxygen species (ROS) production because it metabolizes 20% of total body oxygen and has a short amount of antioxidant potential. Continuous control of psychostimulants such as methylphenidate, m-amphetamine, and d-amphetamine in rats caused enhanced superoxide production, oxidative harm to protein, lipid, and DNA, and changes in enzymes antioxidants, and the mitochondrial respiratory chain complexes.

This drug may create side effects. Inform your doctor if any of these signs are critical or do not go away:

  • headache
  • dizziness
  • difficulty falling asleep or staying asleep
  • drowsiness
  • nausea
  • diarrhea
  • constipation
  • gas
  • heartburn
  • loss of appetite
  • unusual tastes
  • dry mouth
  • excessive thirst
  • nosebleed
  • flushing
  • sweating
  • tight muscles or difficulty moving
  • back pain
  • confusion
  • uncontrollable shaking of a part of your body
  • burning, tingling, or numbness of the skin
  • difficulty seeing or eye pain

Some harsh effects can be dangerous. If you feel any of these signs, call your doctor quickly:

  • rash
  • blisters
  • peeling skin
  • mouth sores
  • hives
  • itching
  • hoarseness
  • difficulty breathing or swallowing
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • chest pain
  • fast, pounding, or irregular heartbeat
  • frenzied, abnormally excited mood
  • hallucinating (seeing things or hearing voices that do not exist)
  • anxiety
  • depression
  • thinking about killing or harming yourself

Modafinil is also used along with breathing devices or other ways to stop extreme sleepiness caused by obstructive sleep apnea/hypopnea symptoms (OSAHS; a sleep disorder in which the victim shortly stops breathing or breathes shallowly several times throughout sleep and hence does not get sufficient restful sleep). This drug is in a class of medicines called wakefulness-promoting agents. It acts by increasing the amounts of specific natural substances in the area of the brain that regulates sleep and alertness.

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